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Related Experiment Videos

Haemodilution induces a hypercoagulable state

T G Ruttmann1, M F James, J F Viljoen

  • 1Department of Anaesthesia, University of Cape Town Medical School, South Africa.

British Journal of Anaesthesia
|March 1, 1996
PubMed
Summary
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Haemodilution using saline or Haemaccel increases whole blood coagulation in vitro. Saline dilution significantly impacts clot strength, suggesting careful consideration during medical procedures involving fluid replacement.

Area of Science:

  • Biochemistry
  • Hematology
  • Medical Research

Background:

  • Haemodilution is a common practice in medical procedures.
  • The impact of different diluents on blood coagulation requires further investigation.

Purpose of the Study:

  • To investigate the effect of in vitro haemodilution with saline and Haemaccel on whole blood coagulation.
  • To compare the coagulation changes induced by different diluents using thrombelastography.

Main Methods:

  • In vitro dilution of whole blood with 0.9% saline or Haemaccel.
  • Coagulation parameters were measured using thrombelastogram (TEG).
  • Comparison of diluted samples with undiluted controls from the same subjects.

Main Results:

Related Experiment Videos

  • Both saline and Haemaccel dilutions decreased r time, k time, and r + k time, indicating faster clot formation.
  • Alpha angles increased in both groups, suggesting enhanced clot kinetics.
  • Maximum amplitude was unaffected by Haemaccel but potentially altered by saline (implied by contrast with Haemaccel).

Conclusions:

  • Haemodilution itself enhances in vitro whole blood coagulability.
  • Saline haemodilution demonstrates a more pronounced effect on the final clot strength compared to Haemaccel.