Ascorbic acid preferentially enhances type I and III collagen gene transcription in human skin fibroblasts
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1Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Journal of Dermatological Science
|March 1, 1996
Abstract:
Ascorbic acid is a potent stimulator for type I and III collagen expression in human skin fibroblasts; stimulation of type I and III collagen synthesis and their mRNA levels by ascorbic acid has been reported previously. Nuclear run-on experiments demonstrated that ascorbic acid enhanced the transcription of type I and III collagen genes 4- and 3.4-fold respectively, whereas transcription of type IV collagen was slightly stimulated (1.7-fold). The results suggest that ascorbic acid preferentially enhanced type I and III collagen transcription.