Effect of enzyme organization on the stability of Yates-Pardee pathways
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Updated: Nov 4, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
1Institut de Biologie Théorique, Angers, France. ybteam@snv.jussieu.fr
Abstract:
Yates-Pardee-type metabolic pathways in a heterogeneous cell milieu are modeled as a system of coupled non-linear partial differential equations. A numerical solution to this system is described and some properties of such a physiological system are studied. Confinement with and without a membrane is considered and it is shown how confinement results in an increase in the stability of the metabolite concentrations. These results suggest that the enzyme organization may contribute to the stability of the cellular metabolism.
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