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Particle Agglutination Method for Poliovirus Identification
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Evaluation of new approaches to poliovirus vaccine neurovirulence tests

D J Wood1

  • 1National Institute for Biological Standards and Control, Potters Bar Herts, UK.

Developments in Biological Standardization
|January 1, 1996
PubMed

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Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...