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A new polymethylmethacrylate membrane for hemodialysis
M Bonomini1, B Fiederling, T Bucciarelli
1Institute of Nephrology, G. D'Annunzio University, Chieti, Italy.
The International Journal of Artificial Organs
|April 1, 1996
Summary
A new hemodialysis (HD) membrane, Filtryzer BK-F, effectively removes high molecular weight (MW) solutes like beta 2-microglobulin (beta 2-M). This advanced membrane shows promise in managing long-term HD complications such as anemia and amyloid formation.
Area of Science:
- Nephrology
- Biomaterials Science
Background:
- High molecular weight (MW) solutes accumulate during conventional hemodialysis (HD), contributing to long-term complications.
- These complications include anemia, bone and joint pain, neuropathy, and itching.
Purpose of the Study:
- To evaluate the in vivo HD removal capacity of a new polymethylmethacrylate (PMMA) membrane (Filtryzer BK-F).
- To compare BK-F's performance against conventional PMMA (BK-P) and cellulose acetate (CA) membranes for high MW solute removal.
Main Methods:
- A randomized crossover trial involving ten stable anuric RDT patients.
- Patients were treated with BK-F, BK-P, and CA membranes for one week each.
- Plasma concentrations of creatinine, BUN, and beta 2-microglobulin (beta 2-M) were measured pre- and post-HD.
- Dialysate was analyzed using HPLC to assess MW solute profiles.
Main Results:
- The reduction rates for BUN and creatinine were similar across all three membranes.
- BK-F demonstrated significantly higher beta 2-M reduction rates compared to BK-P and CA (p < 0.005 and p < 0.0001, respectively).
- HPLC analysis revealed BK-F effectively removed solutes > 50 kDa, including those > 500 kDa, unlike BK-P and CA which primarily removed < 4 kDa solutes.
Conclusions:
- The BK-F membrane offers superior removal of high MW substances during hemodialysis.
- This enhanced removal capacity may help prevent or manage long-term HD complications like anemia and beta 2-M amyloidosis.