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Changes in extrahepatic biliary motilities with emesis in dogs
1Department of Physiology, Kawasaki Medical School, Kurashiki, Japan.
Journal of the Autonomic Nervous System
|December 5, 1995
Summary
During vomiting, gallbladder contractions increase, but bile flow is blocked because the sphincter of Oddi also contracts. This study investigated biliary system motility changes during emesis in dogs.
Area of Science:
- Gastroenterology
- Neurogastroenterology
- Biliary Physiology
Background:
- Emesis involves complex physiological responses affecting the gastrointestinal tract.
- The role of the extrahepatic biliary system during emesis is not fully understood.
Purpose of the Study:
- To investigate changes in gallbladder and sphincter of Oddi motility during emesis.
- To determine the impact of vagal nerve stimulation on biliary motility during retching.
Main Methods:
- Measurements of gallbladder volume, sphincter of Oddi resistance, and duodenal/antral contractility in decerebrate, paralyzed dogs.
- Elicitation of fictive retching via thoracic vagus nerve stimulation.
- Assessment of serum gastrin and plasma cholecystokinin levels.
Main Results:
- Vagal stimulation enhanced gallbladder, sphincter of Oddi, and duodenal/antral motility during retching.
- Sphincter of Oddi and duodenal motility showed transient depression at retching onset.
- Bile evacuation is interrupted during emesis due to simultaneous contraction of the gallbladder and sphincter of Oddi.
Conclusions:
- Emesis causes simultaneous contraction of the gallbladder and sphincter of Oddi, impeding bile flow.
- Vagal nerve pathways play a crucial role in mediating these motility changes.
- Understanding these mechanisms is vital for managing conditions associated with emesis.