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Corpora amylacea: a marker for mesial temporal sclerosis

M H Chung1, D S Horoupian

  • 1Division of Neuropathology, Stanford University Medical Center, California 94305-5324, USA.

Journal of Neuropathology and Experimental Neurology
|April 1, 1996
PubMed
Summary

Corpora amylacea (CoA) are frequently found with mesial temporal sclerosis (MTS), a common cause of intractable epilepsy. Abundant CoA can serve as a diagnostic marker for MTS when neuronal loss is unclear.

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Area of Science:

  • Neuropathology
  • Epilepsy Research
  • Histopathology

Background:

  • Mesial temporal sclerosis (MTS) is the primary pathology in temporal lobectomies for intractable seizures.
  • Diagnosing MTS relies on identifying hippocampal neuronal loss, which can be challenging in non-en bloc resections.
  • Indeterminate hippocampal pathology is a common issue in epilepsy surgery evaluations.

Purpose of the Study:

  • To investigate the association between corpora amylacea (CoA) and mesial temporal sclerosis (MTS).
  • To evaluate the utility of CoA as a diagnostic marker for MTS in epilepsy surgery specimens.
  • To recommend optimal staining techniques for identifying CoA in resected temporal lobe tissues.

Main Methods:

  • Retrospective analysis of 73 temporal lobectomies performed for seizure disorders.

Related Experiment Videos

  • Histopathological examination of hippocampal and amygdala tissues.
  • Staining with LFB-PAS to highlight corpora amylacea (CoA).

    • Main Results:

    • Increased numbers of corpora amylacea (CoA) were observed in 58% of cases with mesial temporal sclerosis (MTS).
    • Corpora amylacea (CoA) presence was associated with MTS, offering a potential diagnostic marker.
    • The identification of abundant CoA can aid diagnosis when neuronal loss is difficult to assess.

    Conclusions:

    • Corpora amylacea (CoA) are frequently associated with mesial temporal sclerosis (MTS).
    • Abundant CoA serves as a valuable histological marker for MTS, especially when neuronal loss is equivocal.
    • LFB-PAS staining of hippocampal and amygdala tissues is recommended for highlighting CoA in temporal lobe epilepsy evaluations.