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Related Experiment Videos

[Altered thyroid in dialysed uremic patients]

F Benati1, A Lupo, R Dorizzi

  • 1Regione Veneto, USSL 26 - Ospedale di Caprino (Verona).

Minerva Endocrinologica
|March 1, 1996
PubMed
Summary
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Uremic patients frequently exhibit thyroid abnormalities, with hemodialysis patients showing higher rates than peritoneal dialysis patients. Routine thyroid screening is recommended for chronic renal insufficiency patients.

Area of Science:

  • Nephrology
  • Endocrinology
  • Internal Medicine

Background:

  • Uremia, a condition of chronic kidney disease, can significantly impact endocrine function, particularly thyroid hormone metabolism.
  • Previous studies suggest a high prevalence of thyroid dysfunction in patients with renal failure.

Purpose of the Study:

  • To investigate the spectrum and frequency of thyroid abnormalities in uremic patients undergoing different dialysis modalities.
  • To assess various thyroid function parameters and autoantibodies in this population.

Main Methods:

  • Studied 40 uremic patients (20 hemodialysis, 20 peritoneal dialysis).
  • Assessed total/free thyroxine, total/free triiodothyronine, thyrotropin (TSH), TSH response to TRH, reverse T3, thyroglobulin, and thyroid autoantibodies (antithyroglobulin, antimicrosomial, antithyroperoxidase).

Related Experiment Videos

  • Performed thyroid echography and diagnosed specific thyroid conditions.

    • Main Results:

    • 75% of uremic patients displayed thyroid alterations; hemodialysis patients had a higher incidence (65%) than peritoneal dialysis patients (52.5%).
    • Significantly reduced total thyroxine and free triiodothyronine levels were observed.
    • Diagnoses included sick euthyroid syndrome, goiters, hypothyroidism, and surprisingly, toxic multinodular goiter and pretoxic Plummer's adenoma.

    Conclusions:

    • Uremic patients have a high incidence of thyroid dysfunction, affecting hypo-, normo-, and hyperthyroid states.
    • Routine thyrotropin assessment is crucial for all uremic patients.
    • Chronic renal insufficiency patients are at risk for various thyreopathies, necessitating comprehensive thyroid evaluation.