Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-related decrease in vulnerability to excitatory amino acids in the nucleus basalis

G L Wenk1, J D Stoehr, S L Mobley

  • 1Division of Neural Systems, Memory & Aging, University of Arizona, Tucson 85724, USA.

Neurobiology of Aging
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patterns of treatment prior to death among those with lung cancer: A national study in a universal healthcare context.

Lung cancer (Amsterdam, Netherlands)·2025
Same author

Translational challenges and opportunities in biofilm science: a BRIEF for the future.

NPJ biofilms and microbiomes·2022
Same author

Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory.

Neurobiology of learning and memory·2016
Same author

The benefits and harms of rheumatic heart disease screening from the perspective of the screened population.

International journal of cardiology·2016
Same author

Problems+Solutions.

Postgraduate medicine·2016
Same author

Cannabis exposure and risk of testicular cancer: a systematic review and meta-analysis.

BMC cancer·2015
Same journal

Hippocampal-cortical structural networks in the progression of cognitive impairment: A source-based morphometry analysis in individuals with subjective cognitive decline, mild cognitive impairment and Alzheimer's disease.

Neurobiology of aging·2026
Same journal

Brain structure in the cingulate cortex and locus coeruleus in late life is associated with engagement in complex mental activities across the life span.

Neurobiology of aging·2026
Same journal

Age-related differences in motor learning, sensorimotor neurochemistry, and cortical reactivity co-occur but are dissociated.

Neurobiology of aging·2026
Same journal

How cognition and hearing-related measures covary with hippocampal subfield features from structural MRI in younger and older adults.

Neurobiology of aging·2026
Same journal

Decreased awareness of cognitive decline is associated with multimodal Alzheimer's disease biomarkers in cognitively unimpaired individuals.

Neurobiology of aging·2026
Same journal

Review of current research practices in social and structural determinants of health data collection in Canadian longitudinal cohorts of aging and dementia.

Neurobiology of aging·2026
See all related articles

Nucleus basalis magnocellularis (NBM) lesions impaired T-maze performance in rats of all ages. Young rats showed the most significant impairment following NBM lesions, particularly under challenging conditions.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Aging Research

Background:

  • The nucleus basalis magnocellularis (NBM) plays a crucial role in cognitive functions.
  • Age-related cognitive decline is a significant concern, and understanding its neural underpinnings is vital.
  • The impact of NBM lesions on cognitive performance across different age groups requires further investigation.

Purpose of the Study:

  • To investigate the effects of nucleus basalis magnocellularis (NBM) lesions on cognitive performance in young, adult, and aged rats.
  • To examine how NMDA or AMPA-induced lesions in the NBM affect performance in a delayed alternation task.
  • To determine if age influences the impact of NBM lesions on a T-maze task.

Main Methods:

  • Lesions were induced in the NBM of rats aged 3, 9, and 24 months using NMDA or AMPA injections.

Related Experiment Videos

  • Rats were tested on a T-maze delayed alternation task with varying interchoice intervals (ICIs) across three phases (5s, 30s, 5s).
  • Performance was assessed based on choice accuracy, with statistical analyses (ANOVA) applied to evaluate age and lesion effects.

    • Main Results:

    • Older rats (24 months) performed worse than younger rats (3 months) in the initial phase (5s ICI).
    • NBM lesions equally impaired choice accuracy across all age groups when the ICI was longer (30s).
    • In the final phase (5s ICI, increased trials), a significant interaction revealed that young rats were more impaired by NBM lesions than aged rats.

    Conclusions:

    • NBM integrity is crucial for cognitive performance, with age influencing vulnerability to lesions.
    • While NBM lesions universally impair performance, younger animals exhibit greater sensitivity to these deficits under specific task demands.
    • These findings highlight the complex interplay between age, NBM function, and cognitive flexibility.