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[POEMS syndrome: role and value of interleukin-6]
E Andrès1, F Courouau, G Kaltenbach
1Service de médecine interne, CHU de Strasbourg, hôpital de Hautepierre, France.
La Revue De Medecine Interne
|January 1, 1996
Abstract:
POEMS syndrome is a systemic disorder with peripheral neuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. The association of POEMS syndrome with lympho-proliferative disorder is very commun. The pathogenesis remains poorly understood but implication of cytokines (interleukins 1 and 6) is suspected. We report a case of a classic POEMS syndrome (with polyneuropathy, hepatomegaly, diabetes melitus, hyperpigmentation, monoclonal IgG lambda, anasarca and solitary plasmocytoma), associated with high serum levels of interleukin 6.