[Activity of some enzymes of the cerebrospinal fluid in lumbar disk hernia]

Enzyme activity of Acetylcholinesterase (E.C.3.1.1.7.), Glutamicoxalacetic-transminase (E.C.2.6.1.1.), Glutamic-piruvic-transaminase (E.C.2.6.1.2.), and Creatine-phosphokinase (E.C.2.7.3.2.) are significantly elevated in cerebrospinal fluid of patients with prolapsed lumbar discs lesions. Origin of elevated enzyme activities is from radiculitis which arosed because of root compression by prolapsed disk. There is also wide communication between spinal subarachnoidal space and lymphatic path of spinal roots, and because of that it is possible to note elevated enzyme activities in cerebrospinal fluid of the lubar sac. Elevation of enzyme activity is different of every investigated enzyme. This different elevations point to reversible and mild damage of cells and do not point to the cell necrosis in cases of prolapsed discs lesions. Determination of enzyme activities in cerebrospinal fluid could be clinically valid test.