Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of anesthetics activity by electroacupuncture on Jen-Chung point in rabbits

C L Chang1, J C Lee, C C Tseng

  • 1Department of Anesthesiology, National Cheng Kung University, Tainan City, Taiwan, ROC.

Neuroscience Letters
|December 29, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Limits on Light Dark Matter Interactions in a Low Threshold Two-Channel Athermal Phonon Detector from the TESSERACT Collaboration.

Physical review letters·2025
Same author

First demonstration of a TES based cryogenic Li <math></math> MoO <math></math> detector for neutrinoless double beta decay search.

The European physical journal. C, Particles and fields·2025
Same author

First Constraints on the Epoch of Reionization Using the Non-Gaussianity of the Kinematic Sunyaev-Zel'dovich Effect from the South Pole Telescope and Herschel-SPIRE Observations.

Physical review letters·2024
Same author

Prenatal exposure to nickel and atopic dermatitis at age 3 years: a birth cohort study with cytokine profiles.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Evaluation of an automated specimen processing system for staining and culture for acid-fast bacilli.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021
Same author

Identification of a novel HLA-DQB1 allele, HLA-DQB1*03:168, by sequence-based typing in a Taiwanese individual.

HLA·2020
Same journal

Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.

Neuroscience letters·2026
Same journal

Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.

Neuroscience letters·2026
Same journal

Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats.

Neuroscience letters·2026
Same journal

Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation.

Neuroscience letters·2026
Same journal

Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study.

Neuroscience letters·2026
Same journal

Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

Neuroscience letters·2026
See all related articles

Electroacupuncture (EA) at the Jen-Chung point shortens anesthetic-induced sleep time in rabbits. This effect is mediated by noradrenergic neurotransmission, not opioids or serotonin.

Area of Science:

  • Neuroscience
  • Acupuncture Research
  • Anesthesiology

Background:

  • Anesthetics like pentobarbital and propofol induce central nervous system depression.
  • Acupuncture is a traditional practice with potential modulatory effects on physiological processes.
  • The specific mechanisms by which acupuncture influences anesthetic effects are not fully understood.

Purpose of the Study:

  • To investigate the effect of electroacupuncture (EA) at the Jen-Chung point on the central nervous depressive action of anesthetics.
  • To explore the potential involvement of endogenous opioids and serotonin in EA's modulatory effects.
  • To elucidate the neurotransmitter systems mediating EA's influence on anesthetic-induced sedation.

Main Methods:

  • Rabbits were administered pentobarbital or propofol to induce anesthesia.

Related Experiment Videos

  • Electroacupuncture (EA) was applied to the Jen-Chung point.
  • Pharmacological agents including naloxone, para-chlorophenylalanine, prazosin, and guanethidine were used to block specific neurotransmitter pathways.
  • Plasma beta-endorphin levels were measured using radioimmunoassay.
  • Sleeping time was recorded to quantify anesthetic effects.

    • Main Results:

    • EA stimulation at the Jen-Chung point significantly decreased the sleeping time induced by pentobarbital and propofol.
    • Naloxone and para-chlorophenylalanine did not alter the effect of EA, ruling out opioid and serotonin mediation.
    • Plasma beta-endorphin levels showed no significant change with EA.
    • Prazosin dose-dependently reversed the sleeping time-reducing effect of EA.
    • Guanethidine administration blocked the action of EA, indicating noradrenergic involvement.

    Conclusions:

    • Stimulation of the Jen-Chung point via EA activates brain noradrenergic neurotransmission.
    • This activated noradrenergic pathway subsequently reduces the central nervous depressive effects of anesthetics.
    • The findings suggest a novel mechanism for acupuncture in modulating anesthetic depth through the noradrenergic system.