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Characterization of the plasmidic beta-lactamase CMY-2, which is responsible for cephamycin resistance
A Bauernfeind1, I Stemplinger, R Jungwirth
1Max von Pettenkofer-Institut, Munich, Germany.
Antimicrobial Agents and Chemotherapy
|January 1, 1996
Abstract:
The phenotype of Klebsiella pneumoniae HEL-1 indicates a plasmidic cephamycinase gene (blaCMY-2). Its sequence shows one open reading frame coding for a protein of 381 amino acids. CMY-2 is classified as class C beta-lactamase that is closely related to the plasmidic enzymes BIL-1 and LAT-1 and the chromosomal AmpC of Citrobacter freundii. The blaCMY-2 gene possibly was translocated onto a plasmid of C. freundii which spread to K. pneumoniae.