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Simple in vitro translation assay to analyze inhibitors of rhinovirus proteases
1Infectious Disease Research, Lilly Research Laboratories, Indianapolis, Indiana 46285, USA.
Antimicrobial Agents and Chemotherapy
|January 1, 1996
Abstract:
We have developed a simple in vitro translation method to analyze compounds that inhibit the rhinovirus 3C protease in peptide substrate assays but demonstrate no antiviral activity. This complementary assay, which provides both qualitative and quantitative results, detects the inhibition of the 3CD protease in the native polyprotein form.