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Screening a 2 cM genetic map for allelic association: a simulated oligogenic trait
1Queensland Institute of Medical Research, Brisbane, Australia.
Genetic Epidemiology
|January 1, 1995
Abstract:
In this paper, we explore the use of a variety of familial transmission tests (and case-control analyses) to screen for allelic associations in simulated marker data of a quality (2 cM map) that will feasibly arise from genomic scans within the next 5-10 years. We demonstrate a form of the transmission-disequilibrium test extended to multiallele systems. The methods used were log-linear and related models implemented largely using standard statistical packages.