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TDT with covariates and genomic screens with mod scores: their behavior on simulated data
J P Rice1, R J Neuman, S L Hoshaw
1Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Genetic Epidemiology
|January 1, 1995
Abstract:
We describe an extension to the TDT (transmission/disequilibrium test) which allows for more than two marker alleles and for covariates measured on the parent or offspring. We also describe a systematic genomic search where the mod score (maximized lod score) is computed for each marker under constraints on the population prevalence or penetrances of a single locus.