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Detection of genome similarity as an exploratory tool for mapping complex traits
1Department of Biostatistics, University of Michigan, Ann Arbor 48109-2029, USA.
Abstract:
For one- and two-trait-locus models, we show that the lod score based on affected relative pairs or trios is a monotonically increasing function of the genome similarity measured by the proportion of alleles shared identical by descent (IBD) conditional on observed marker data. These results can be generalized to multitrait-locus models. Thus, we can use conditional probability of genes shared IBD as a tool to reveal chromosomal segments that are likely to harbor the genes underlying the complex traits.
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