Prostaglandins play a role in memory consolidation in the chick

Previous studies showed that inhibitors of cyclooxygenases have amnesic effects in chicks in a passive avoidance task. The onset of amnesia has a delay of 2 h post-training. To investigate if this effect is due to the inhibition of induction of the enzyme during learning, the release of cyclooxygenase products into the extracellular fluid was measured at 1, 2 and 3 h post-training. A cyclooxygenase inhibitor, ibuprofen, inhibited the training-dependent increase of cyclooxygenase products only 2 h and 3 h after learning when injected pre-training, as did dexamethasone which prevents cyclooxygenase induction, and SC58125 (1,2-diarylcyclopentene), an inhibitor of inducible cyclooxygenase. Injections 30 min post-training showed the same effect with the exception of dexamethasone. Injecting SC58125, ibuprofen, indomethacin, or dexamethasone i.c. before training showed amnesic effects for training on a one-trial passive avoidance task at 2 h but not 1 h after training. Injections 30 min post-training produced the same effects with the exception of dexamethasone. I conclude that cyclooxygenases are induced during training and that cyclooxygenase products are of importance in memory formation of the chick.