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Cross-generalization between a cocaine cue and two antihistamines
D V Gauvin1, K L Carl, R J Briscoe
1Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 3190-3000, USA.
European Journal of Pharmacology
|December 27, 1995
Summary
Rats generalized to cocaine doses, showing similar effects to the training dose. Antihistamines like diphenhydramine and doxylamine partially mimicked cocaine
Area of Science:
- Pharmacology
- Behavioral Neuroscience
Background:
- Cocaine's discriminative stimulus properties are well-established.
- Understanding drug generalization is crucial for predicting behavioral effects.
Purpose of the Study:
- To assess cocaine dose-generalization.
- To investigate cross-generalization of antihistamines (diphenhydramine, doxylamine) with cocaine's stimulus effects.
- To examine drug combinations.
Main Methods:
- Rats were trained to discriminate 10 mg/kg cocaine from saline.
- Generalization tests included various cocaine doses, diphenhydramine, doxylamine, and drug combinations.
- Behavioral responses were measured under a fixed ratio 10 schedule.
Main Results:
- Cocaine produced dose-dependent generalization to its own training stimulus.
- Diphenhydramine and doxylamine showed partial generalization to the cocaine cue.
- Drug mixtures resulted in complete cross-generalization with the cocaine training stimulus.
- Cocaine exhibited biphasic effects on response rates.
Conclusions:
- Cocaine's discriminative stimulus effects generalize in a dose-dependent manner.
- Diphenhydramine and doxylamine share some stimulus properties with cocaine.
- Combined administration of these drugs leads to complete stimulus generalization, indicating significant drug interactions.