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The antipsychotic potential of subtype-selective 5-HT receptor ligands based on interactions with mesolimbic dopamine
1Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Essex, UK. mark.tricklebank@gwa.sandoz.com
Behavioural Brain Research
|January 1, 1996
Abstract:
Many neurochemical, electrophysiological and behavioural studies have shown how 5-HT and dopamine neuronal systems are able to interact and it is highly likely that the therapeutic benefits of clozapine-like atypical antipsychotic drugs are achieved by the modulation of such interactions. There are, however, at least fourteen subtypes of 5-HT receptor and five subtypes of dopamine receptor expressed in rodent and/or human brain and the optimum combination of receptor affinities required for maximum therapeutic benefit remains enigmatic.