Adverse effects of established and new antiepileptic drugs: an attempted comparison

Seizures are but one aspect of the negative impact epilepsy has on patients' lives. Adverse effects of antiepileptic treatment may affect the patient's quality of life to an even greater extent than the occurrence of seizures. Adverse effects of antiepileptic drugs (AEDs) are common, and because the differences in efficacy are often marginal, adverse effects may be the most important factor in choosing the best AED for the patient. The search for more efficient and less toxic agents is constantly ongoing. Current evidence suggests that the new generation of AEDs is as efficient as the established AEDs and exhibits fewer adverse effects, but the scientific evidence from randomised clinical trials comparing established and new AEDs with each other is still pending.