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Amphotericin B infused in 20% lipid emulsion
1Providence Home Infusion, Portland, Oregon, USA.
Summary
Amphotericin B, an essential antifungal, can cause adverse effects. This review examines traditional D5W solutions versus lipid emulsions for administration, focusing on minimizing toxicity.
Area of Science:
- Mycology
- Pharmacology
- Clinical Pharmacy
Background:
- Amphotericin B is a critical antifungal agent for specific infections.
- Its use is often limited by significant renal toxicity and other adverse effects.
- Traditional administration involves slow infusion in dextrose 5% in water (D5W) with supportive care.
Purpose of the Study:
- To review and compare administration protocols for Amphotericin B.
- To evaluate the use of lipid emulsion as an alternative diluent to D5W.
- To analyze methods for mitigating Amphotericin B-associated toxicities.
Main Methods:
- Comparative review of existing literature on Amphotericin B administration.
- Examination of protocols using D5W solutions.
- Analysis of studies employing lipid emulsions (20%) as a diluent.
- Assessment of challenges related to infusion volume and duration with lipid emulsions.
Main Results:
- Traditional D5W infusion requires prolonged administration (4-6 hours) with hydration and supportive measures.
- Lipid emulsion formulations aim to reduce Amphotericin B toxicity.
- Challenges exist in adapting lipid emulsion protocols due to volume and infusion time constraints.
Conclusions:
- Both D5W and lipid emulsion methods have specific administration protocols.
- The article examines these protocols but does not endorse lipid solutions.
- Understanding administration nuances is key to managing Amphotericin B's therapeutic index.