Neuroprotection and selective vulnerability of neurons within the nucleus basalis magnocellularis

Neurons within the nucleus basalis may die due to their selective vulnerability to endogenous excitatory amino acid neurotransmitters, nitric oxide and free radicals. The factors influencing the selective vulnerability of neurons within the nucleus basalis depend upon many different factors related to the presence of these agents and the neuron's ability to defend itself against the consequences of exposure. Many different mechanisms have been investigated to provide neuroprotection for neurons within the nucleus basalis and throughout the central nervous system. This review summarizes the results of studies that have investigated our current capability to either attenuate the neurotoxicity of endogenous excitatory amino acids, such as glutamate, or to provide effective neuroprotection during circumstances of neurotoxin exposure.