Autoantigen-induced deletion of peripheral self-reactive T cells

There are now numerous reports documenting the deletion of mature peripheral specific T cells following massive antigenic stimulation. Such a phenomenon can be regarded as a homeostatic mechanism to prevent unrestricted growth of antigen-activated clones and to safeguard against autoimmunity. Some of the reports examining this issue are summarized in this review and the role of the liver in tolerance and autoimmunity is discussed based on recent work performed with transgenic mice.