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Sweat testing for benzodiazepines

P Kintz1, A Tracqui, P Mangin

  • 1Institut de Médecine Légale, Strasbourg, France.

Journal of Forensic Sciences
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

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This study shows that diazepam and its metabolite nordiazepam can be detected in sweat for up to a week using a sweat patch. This technology may help document drug use over extended periods.

Area of Science:

  • Pharmacology
  • Analytical Chemistry
  • Forensic Toxicology

Background:

  • Diazepam is a commonly prescribed medication.
  • Monitoring drug excretion is crucial for clinical and forensic applications.
  • Novel methods for drug monitoring are continuously being developed.

Purpose of the Study:

  • To determine diazepam and metabolite excretion in sweat.
  • To investigate the time course and dose-concentration relationship of diazepam in sweat.
  • To evaluate the utility of sweat patch technology for drug surveillance.

Main Methods:

  • Clinical study involving thirteen subjects orally administered single doses of diazepam.
  • Sweat collection using Sudormed sweat patches over one week.
  • Quantification of diazepam and its metabolites (nordiazepam, oxazepam) using gas chromatography/mass spectrometry (GC/MS).

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Main Results:

  • Diazepam and nordiazepam were consistently detected in sweat patches; oxazepam was not detected.
  • Drugs were detectable within 2–4 hours post-administration, with peak concentrations between 48–72 hours.
  • Concentrations ranged from 0.1 to 6.0 ng/patch, showing a potential dose-related trend.
  • The sweat patch allowed for drug detection over a week-long surveillance period.

Conclusions:

  • The sweat patch is a viable tool for monitoring diazepam use over an extended period.
  • This technology offers a non-invasive method for drug surveillance.
  • Further research can explore its application for other drugs and longer-term monitoring.