Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Schizophrenia

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.

Negative and Cognitive Symptoms of Schizophrenia

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

Psychological and Sociocultural Causes of Schizophrenia

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical symptoms of schizophrenia affect reference-independent measures of task-induced EEG alpha asymmetry.

Psychiatry research·1997

Same author

Asymmetry of temporal lobe phosphorous metabolism in schizophrenia: a 31phosphorous magnetic resonance spectroscopic imaging study.

Biological psychiatry·1995

Same author

Correlation between left frontal phospholipids and Wisconsin Card Sort Test performance in schizophrenia.

Schizophrenia research·1995

Same author

Basal ganglia phosphorous metabolism in chronic schizophrenia.

The American journal of psychiatry·1995

Same author

31phosphorus magnetic resonance spectroscopy of the frontal and parietal lobes in chronic schizophrenia.

Biological psychiatry·1994

Same author

P300 responses to novel auditory stimuli in hospitalized schizophrenic patients.

Biological psychiatry·1994

Search research articles

Related Experiment Video

Updated: Jul 28, 2026

EEG Mu Rhythm in Typical and Atypical Development

EEG Mu Rhythm in Typical and Atypical Development

Published on: April 9, 2014

Negative symptoms and EEG alpha in schizophrenia: a replication

E L Merrin¹, T C Floyd

¹Psychiatry Service (116N), DVA Medical Center, San Francisco, CA 94121, USA.

Schizophrenia Research

|May 1, 1996

Summary

Schizophrenia patients with negative symptoms show reduced alpha power and coherence in brain activity. This replication study confirms these EEG findings, suggesting implications for understanding schizophrenia's neurobiology.

More Related Videos

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

Related Experiment Videos

Last Updated: Jul 28, 2026

EEG Mu Rhythm in Typical and Atypical Development

EEG Mu Rhythm in Typical and Atypical Development

Published on: April 9, 2014

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

Published on: November 19, 2014

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

Area of Science:

Neuroscience
Psychiatry
Electroencephalography (EEG)

Background:

Previous research indicated reduced EEG alpha power and coherence in medication-free schizophrenia patients.
These findings were based on resting EEG data with eyes open.

Purpose of the Study:

To replicate earlier findings on the association between negative symptoms and EEG alpha activity in a new sample.
To examine the relationship between resting alpha power/coherence and symptom ratings in schizophrenia.

Main Methods:

Utilized multivariate repeated measure analyses of covariance.
Analyzed resting EEG alpha (7.5-12.5 Hz) power and coherence in 17 recently hospitalized, medication-free male veterans with schizophrenia.
Correlated EEG data with symptom ratings from the Brief Psychiatric Rating Scale.

Main Results:

Replicated previous findings: negative symptoms were significantly associated with reduced log alpha power (p = 0.05).
Observed significant reductions in right frontal-parietal alpha coherence (p < 0.02) and between-hemisphere alpha coherence (p < 0.03) linked to negative symptoms.
A trend indicated asymmetrical alpha power effects, favoring the right parietal leads.

Conclusions:

Negative symptoms in schizophrenia are robustly associated with decreased alpha power and impaired alpha coherence.
Findings support implications for neurodevelopmental, genetic, and attentional models of schizophrenia.
The study highlights the utility of EEG measures in characterizing schizophrenia symptomatology.