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Stereotactic coordinates from ECT sinograms for radionuclide-guided breast biopsy

R R Raylman¹, E P Ficaro, R L Wahl

¹Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, USA.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine

|September 1, 1996

Summary

A new method uses emission scanner sinogram data to precisely locate radiolabeled tumors for image-guided biopsy. This technique accurately guides biopsies of simulated breast cancers, improving diagnostic accuracy.

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Area of Science:

Medical Imaging
Nuclear Medicine
Biopsy Guidance

Background:

Emission scanners (PET/SPECT) detect cancers missed by mammography, CT, or other scans.
Radiopharmaceuticals like 18F-FDG and 99mTc-sestamibi are used for cancer detection.
Sinogram data offers detailed positional information within the scanner's field-of-view.

Purpose of the Study:

To develop and validate a sinogram-based method for guiding tumor biopsies.
To utilize geometric relationships for precise localization of radiopharmaceutical-avid breast masses.

Main Methods:

Calculated object positions using projection views from sinograms.
Compared calculated positions of radioactive spheres (18F, 99mTc) with measured positions.
Performed emission-guided biopsy of simulated lesions using a phantom and a fiducial marker.

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Main Results:

Excellent correlation between calculated and measured object coordinates (R=1.0, R=1.0, R=0.998 for x, y, z).
Maximum localization error was +/- 3 mm.
Achieved 100% success rate in biopsy of simulated tumors (10 of 10).

Conclusions:

A rapid method for determining photon-emitting object positions in emission scanners was developed.
The technique does not require standard emission or anatomic images.
This method can be integrated into dedicated or add-on biopsy devices for PET/SPECT cameras.