Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A common evolutionary origin for mitochondria and hydrogenosomes

E T Bui1, P J Bradley, P J Johnson

  • 1Department of Anatomy and Cell Biology, University of California, Los Angeles 90095, USA.

Proceedings of the National Academy of Sciences of the United States of America
|September 3, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Nottingham and Nottinghamshire Hospital for Diseases of the Throat, Ear and Nose (1886-1947): its formation, rise and demise.

The Journal of laryngology and otology·2020
Same author

Provision of surgical voice restoration in England: questionnaire survey of speech and language therapists.

The Journal of laryngology and otology·2013
Same author

Implications of protein import on the origin of hydrogenosomes.

Protist·2012
Same author

Salivary duct carcinoma: what is already known, and can we improve survival?

The Journal of laryngology and otology·2012
Same author

Malignant melanoma of nasal cavity and paranasal sinuses: report of 24 patients and literature review.

The Journal of laryngology and otology·2011
Same author

Effect of device length and background doping on the relative magnitudes of phase and amplitude modulation in GaAs/AIGaAs PIN multiple quantum well waveguide optical modulators: erratum.

Applied optics·2010

Hydrogenosomes in early-branching eukaryotes, like mitochondria, evolved from a common eubacterial ancestor. These organelles contain heat shock proteins, indicating a shared evolutionary origin.

Area of Science:

  • Cell Biology
  • Evolutionary Biology
  • Microbiology

Background:

  • Trichomonads are ancient eukaryotes lacking mitochondria and peroxisomes.
  • They possess hydrogenosomes, organelles involved in carbohydrate metabolism and ATP production.
  • Hydrogenosomes differ from mitochondria, lacking DNA and cytochromes but containing bacterial enzymes and producing hydrogen.

Purpose of the Study:

  • To investigate the evolutionary origin of hydrogenosomes.
  • To determine if hydrogenosomes share a common ancestor with mitochondria.
  • To analyze the phylogenetic relationships of heat shock proteins within hydrogenosomes.

Main Methods:

  • Analysis of heat shock proteins (Hsp70, Hsp60, Hsp10) in hydrogenosomes.
  • Biochemical analysis of hydrogenosomal Hsp60.

Related Experiment Videos

  • Phylogenetic analyses of hydrogenosomal heat shock proteins.

    • Main Results:

    • Hydrogenosomes contain heat shock proteins (Hsp70, Hsp60, Hsp10) with conserved sequences found in mitochondrial and bacterial heat shock proteins.
    • Hydrogenosomal Hsp60 exhibits N-terminal processing similar to mitochondrial proteins.
    • Phylogenetic analyses place hydrogenosomal heat shock proteins within a monophyletic group of mitochondrial homologues.

    Conclusions:

    • Mitochondria and hydrogenosomes share a common eubacterial ancestor.
    • The data suggest that early-branching eukaryotes harbored the endosymbiont that led to mitochondria.
    • This provides evidence for the endosymbiotic theory of mitochondrial evolution.