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Severe, recessive von Willebrand's disease in German Wirehaired Pointers
M Brooks1, S Raymond, J Catalfamo
1Comparative Hematology Section, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Journal of the American Veterinary Medical Association
|September 1, 1996
Summary
German Wirehaired Pointers can develop severe von Willebrand's disease (vWD), characterized by low von Willebrand factor (vWF) and missing high molecular weight multimers. This bleeding disorder is likely an autosomal recessive trait.
Area of Science:
- Veterinary Genetics
- Canine Hemostasis
- Bleeding Disorders
Background:
- Von Willebrand's disease (vWD) is a common inherited bleeding disorder in dogs.
- German Wirehaired Pointers exhibit a severe form of vWD, necessitating further characterization.
Purpose of the Study:
- To investigate the biochemical and genetic underpinnings of a severe vWD form in German Wirehaired Pointers.
- To identify the specific von Willebrand factor (vWF) abnormalities and inheritance patterns.
Main Methods:
- A case series approach was used, analyzing plasma samples from 335 German Wirehaired Pointers, including 8 affected dogs.
- Evaluations included ELISA for vWF antigen concentration, coagulation screening, factor VIII activity assays, and vWF multimeric composition analysis.
Main Results:
- Affected dogs presented with mucosal and cutaneous bleeding by 6 months of age.
- Markedly reduced vWF antigen and absence of high molecular weight vWF multimers were observed, consistent with type-II vWD.
- The inheritance pattern suggests an autosomal recessive trait.
Conclusions:
- Von Willebrand's disease (vWD) should be considered in German Wirehaired Pointers presenting with bleeding issues.
- Definitive diagnosis relies on canine-specific vWF assays to confirm vWD.