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Nonlinear dependence of fish bioconcentration on n-octanol/water partition coefficient
S Bintein1, J Devillers, W Karcher
1CTIS, Lyon, France.
SAR and QSAR in Environmental Research
|January 1, 1993
Abstract:
The log-log relationship between the bioconcentration tendency of organic chemicals in fish and the n -octanol/water partition coefficients breaks down for very hydrophobic compounds. The use of parabolic and bilinear models allows this problem to be overcome. The QSAR equation log BCF = 0.910 log P - 1.975 log (6.8 10(-7) P + 1) - 0.786 (n = 154; r = 0.950; s = 0.347; F = 463.51) was found to be a good predictor of bioconcentration in fish.