Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alterations in cerebral endothelial cell function in ischemia

A L Betz1

  • 1Department of Pediatrics, University of Michigan, Ann Arbor 48109-0532, USA.

Advances in Neurology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frequency and phase-lock control of a 3 THz quantum cascade laser.

Optics letters·2005
Same author

Increased expression of intercellular adhesion molecule-1 in mouse focal cerebral ischemia model.

Chinese medical journal·2002
Same author

Reduction of inflammatory response in the mouse brain with adenoviral-mediated transforming growth factor-ss1 expression.

Stroke·2001
Same author

The University of Utah School of Medicine.

Academic medicine : journal of the Association of American Medical Colleges·2000
Same author

Effect of intracerebral and subdural hematomas on energy-dependent transport across the blood-brain barrier.

Journal of neurotrauma·1999
Same author

Expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 after focal cerebral ischemia in interleukin-1beta converting enzyme deficient mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·1999

Ischemia significantly impacts brain microvascular endothelial cells, disrupting blood-brain barrier functions and contributing to brain damage. These cells are both victims and active participants in ischemic injury.

Area of Science:

  • Neuroscience
  • Cerebrovascular Biology
  • Pathophysiology

Background:

  • Brain microvascular endothelial cells form the blood-brain barrier (BBB), crucial for brain protection.
  • Ischemic events can profoundly alter endothelial cell function.

Purpose of the Study:

  • To investigate the multifaceted effects of ischemia on brain microvascular endothelial cell function.
  • To understand the role of these cells in ischemic brain injury.

Main Methods:

  • Analysis of cellular functions affected by ischemia (details not provided in abstract).
  • Review of literature and data presented in Fig. 2.

Main Results:

  • Ischemia affects nearly all functions of brain microvascular endothelial cells.

Related Experiment Videos

  • Altered BBB functions compromise brain protection.
  • Ischemic conditions promote the production of neurotoxic substances by these cells.

    • Conclusions:

    • Cerebrovascular endothelial cells are key targets in ischemic brain damage.
    • These cells actively participate in the mechanisms causing brain injury during ischemia.