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Chronic cutaneous bacterial hypersensitivity

K S Backman1, K G McGrath, R Patterson

  • 1Division of Allergy-Immunology, Northwestern Memorial Hospital, Chicago, Illinois, USA.

Allergy and Asthma Proceedings
|May 1, 1996
PubMed
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Chronic cutaneous bacterial hypersensitivity (CCBH) is a rare inflammatory skin condition. Oral corticosteroids offer rapid symptom control for CCBH patients, despite challenges in achieving long-term remission.

Area of Science:

  • Immunology
  • Dermatology
  • Microbiology

Background:

  • Chronic cutaneous bacterial hypersensitivity (CCBH) is a syndrome characterized by recurrent inflammatory skin lesions due to hypersensitivity to skin flora.
  • This condition causes significant distress and diagnostic challenges for affected individuals, often involving years of ineffective treatments.
  • CCBH significantly impacts patients' physical and social well-being.

Observation:

  • Two new cases of CCBH are presented, adding to the limited reported instances of this syndrome.
  • Skin testing revealed IgE antibodies to bacterial antigens in both patients.
  • ELISA confirmed both IgE and IgG antibodies to bacterial antigens in one patient.

Findings:

  • Both patients experienced rapid and dramatic improvement with oral corticosteroid therapy, specifically prednisone.

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  • Unlike previous reports, these patients did not achieve lasting remission despite effective short-term symptom control.
  • These cases highlight the effectiveness of a safe and inexpensive prednisone regimen for managing CCBH symptoms.

    • Implications:

    • Oral corticosteroids, particularly prednisone, provide a safe and accessible treatment option for controlling the debilitating symptoms of CCBH.
    • Further research is needed to understand the mechanisms behind the lack of sustained remission in some CCBH patients.
    • Improved diagnostic and therapeutic strategies are crucial for managing this physically and socially destructive dermatological condition.