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Prognostic value of DNA image cytometry in colorectal carcinoma
A Sampedro1, G Urdiales, A Martínez-Nistal
1Image Processing and Cytometry Service, University of Oviedo, Spain.
Objective:
To investigate the diagnostic sensitivity and prognosis predicting of DNA image cytometry in colorectal carcinoma.
Study Design:
We studied the ploidy status and other DNA cytometric parameters in 68 patients with colorectal carcinoma. In addition, clinical-histologic and follow-up information was collected for at least five years.
Results:
DNA histograms were available in all cases, showing a diploid DNA distribution pattern in 6 (8.8%), tetraploid in 21 (30.9%), hyperdiploid in 20 (29.4%) and hypertetraploid in 21 (30.9%). The differences in the correlation study between cytometric parameters and pathologic features were not statistically significant. Ploidy status and DNA malignancy grade were individually related to five-year survival (P < .005 and P < .05).
Conclusion:
The data show that DNA image cytometry can provide valuable prognostic information on colorectal carcinomas and may prove useful in guiding adjuvant therapy in these patients.
