Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calibration methods for automated hematology instruments

P R Gilmer, L J Williams, J A Koepke

    American Journal of Clinical Pathology
    |July 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Long-term life satisfaction in ageing women with work disability due to mental and musculoskeletal disorders.

    Maturitas·2023
    Same author

    Canadian Surgery Forum.

    Canadian journal of surgery. Journal canadien de chirurgie·2022
    Same author

    Comorbidity of mental and musculoskeletal disorders in ageing women: A data linkage study using national registries.

    Maturitas·2021
    Same author

    Validation of a combined ELISA to detect IgG, IgA and IgM antibody responses to SARS-CoV-2 in mild or moderate non-hospitalised patients.

    Journal of immunological methods·2021
    Same author

    Whole blood interleukin-2 release test to detect and characterize rare circulating gluten-specific T cell responses in coeliac disease.

    Clinical and experimental immunology·2021
    Same author

    Repurposing a fracture risk calculator (FRAX) as a screening tool for women at risk for sarcopenia.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020
    Same journal

    Invasive urothelial carcinoma in association with surface low-grade papillary urothelial carcinoma: clinical and pathologic insights from a rare entity.

    American journal of clinical pathology·2026
    Same journal

    CEACAM1 expression by immunohistochemistry in B-cell lymphomas and plasma cell myeloma.

    American journal of clinical pathology·2026
    Same journal

    Comprehensive multicriteria life cycle assessment of biopsy processing in a surgical pathology department.

    American journal of clinical pathology·2026
    Same journal

    Prognostic significance of Myb protein and its downstream target genes in lacrimal gland adenoid cystic carcinoma.

    American journal of clinical pathology·2026
    Same journal

    Mismatch repair protein "nonclassic expression loss" pattern in colorectal cancer: an important staining pattern that is not well understood.

    American journal of clinical pathology·2026
    Same journal

    Musculoskeletal pain in medical laboratory personnel: a cross-sectional study.

    American journal of clinical pathology·2026
    See all related articles

    Automated analyzers have improved blood test accuracy. However, calibration issues persist, requiring better methods for hemoglobin, hematocrit, and cell counts to ensure reliable results.

    Area of Science:

    • Clinical Pathology
    • Laboratory Medicine
    • Hematology

    Background:

    • Recent data show improved reproducibility in hematologic testing.
    • Widespread adoption of automated whole-blood analyzers is a key factor in this improvement.
    • Calibration variability remains a challenge, impacting overall precision.

    Purpose of the Study:

    • To present primary calibration methods for key hematologic parameters.
    • To describe the application of these methods to automated analyzers.
    • To outline techniques for monitoring calibration stability.

    Main Methods:

    • Development and presentation of primary calibration procedures for hemoglobin, hematocrit, and cell counting.
    • Delineation of methods for implementing these calibrations on automated whole-blood analyzers.

    Related Experiment Videos

  • Utilization of preserved reference blood and statistical control techniques for calibration monitoring.

    • Main Results:

    • Established primary calibration methods for essential hematologic tests.
    • Demonstrated practical application of these methods in automated analyzers.
    • Validated the use of reference materials and statistical controls for detecting calibration drift.

    Conclusions:

    • Primary calibration methods and their application are crucial for optimizing automated hematologic analyzers.
    • Continuous monitoring using preserved blood and statistical controls is necessary to maintain accuracy.
    • Addressing calibration variability is essential for further enhancing the precision of hematologic diagnostics.