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Updated: Aug 14, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

Tumor angiogenesis and the role of vascular cell integrin alphavbeta3

J A Varner1, D A Cheresh

  • 1Department of Immunology, Scripps Research Institute La Jolla, California, USA.

Important Advances in Oncology
|January 1, 1996
PubMed

Insights

Targeting angiogenesis, the process tumors use to grow and spread, is a promising cancer therapy. Integrin alpha v beta 3 antagonists induce cancer cell death and tumor regression, offering a potential treatment for solid tumors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Angiogenesis is essential for solid tumor growth and metastasis.
  • Understanding vascular cell mechanisms (proliferation, motility, differentiation) is key.
  • Therapeutic strategies can target angiogenic processes.

Purpose of the Study:

  • To develop strategies inhibiting tumor angiogenesis.
  • To explore the potential of targeting integrin alpha v beta 3.
  • To investigate therapeutic approaches for solid tumors.

Main Methods:

  • Development of antagonists to integrin alpha v beta 3.
  • In vitro and in vivo studies of vascular cell behavior.
  • Designing specific small organic integrin inhibitors.

Main Results:

  • Integrin alpha v beta 3 antagonists induce programmed cell death in new blood vessels.
  • Antagonists promote regression of established human tumors in animal models.
  • Ongoing research focuses on specific small molecule inhibitors.

Conclusions:

  • Targeting angiogenesis via integrin alpha v beta 3 is a viable therapeutic strategy.
  • Integrin antagonists show potential for treating human solid tumors.
  • Further development of specific inhibitors is crucial for clinical application.

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