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Multipin solid-phase synthesis of acyl 2, 3-diaminopropionic acid oligomers
R M Valerio1, A M Bray, K M Stewart
1Chiron Mimotopes Pty Ltd, Clayton, Victoria, Australia.
International Journal of Peptide and Protein Research
|May 1, 1996
Abstract:
A modular approach for the synthesis of sets of diverse organic molecules is described. N-alpha-Fmoc-N-beta-Alloc-D-2,3-diaminopropionic acid (Fmoc-D-Dpr(Alloc)-OH) was prepared in four steps from Boc-D-asparagine and used as a scaffold for attachment of sidechains. Using the Multipin approach, a number of model acyl trimers were rapidly prepared by sequential coupling of Fmoc-D-Dpr(Alloc)-OH and acylation of the beta-amino group with a range of activated carboxylic acids.