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Ex vivo culture systems for hematopoietic cells
P C Collins1, E T Papoutsakis, W M Miller
1Department of Chemical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3120, USA. wmmiller@nwu.edu
Current Opinion in Biotechnology
|April 1, 1996
Abstract:
During the past few years, hematopoietic cell culture technologies for transplantation therapies have progressed significantly on several fronts. Advances include the discoveries of the growth factors thrombopoietin and Flt-3 ligand, the development of a variety of bioreactor systems, and results from preliminary clinical trials that demonstrate the efficacy of ex vivo expanded hematopoietic cells for transplantation therapy.