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Signal transduction through lipid second messengers

S Spiegel¹, D Foster, R Kolesnick

¹Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA.

Current Opinion in Cell Biology

|April 1, 1996

Summary

This review explores glycerolipid and sphingolipid second messengers, their targets, and roles in cell signaling. It details protein kinase C structure and ceramide signaling in apoptosis and inflammation.

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Area of Science:

Biochemistry
Cell Biology
Molecular Biology

Background:

Second messengers like glycerolipids and sphingolipids are crucial in cellular communication.
Understanding their signaling pathways is key to deciphering complex biological processes.

Purpose of the Study:

To review the generation and molecular targets of glycerolipid and sphingolipid second messengers.
To discuss the roles of specific proteins and signaling pathways in cellular events.

Main Methods:

Literature review focusing on signal transduction pathways.
Analysis of protein structures and molecular interactions.

Main Results:

Detailed discussion on phosphatidylinositol transfer protein and phospholipase D in signal transmission.

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Elucidation of protein kinase C structures, including diacylglycerol and calcium-binding sites.

Conclusions:

Ceramide signaling, protein kinases, and cross-talk significantly influence apoptosis and inflammation.
This review consolidates current knowledge on lipid-based signaling networks.