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Updated: Aug 1, 2026
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Bacterial Artificial Chromosomes: A Functional Genomics Tool for the Study of Positive-strand RNA Viruses
Published on: December 29, 2015
Mammalian artificial chromosomes
1William Brown, Raoul Heller, Ming-Hong Shen and Aarti Chand, CRC Chromosome Molecular Biology Group, Biochemistry Department, Oxford University, South Parks Road, Oxford OX1 3QU, UK.
Current Opinion in Genetics & Development
|June 1, 1996
Summary
Researchers are developing mini-chromosome vectors for mouse germline applications. This technology promises to advance genetic research and accelerate gene identification processes.
Area of Science:
- Genetics
- Molecular Biology
- Reproductive Biology
Background:
- The ability to manipulate the mouse germline is crucial for genetic research.
- Existing vector systems have limitations for certain genetic studies.
Purpose of the Study:
- To explore the feasibility of a mini-chromosome vector system for the mouse germline.
- To identify potential applications of such a system in genetic research.
Main Methods:
- Development of candidate mini-chromosome vectors.
- Advancement of sequence-targeting techniques for vector manipulation.
Main Results:
- Candidate vectors and manipulation techniques are progressing.
- A mini-chromosome vector system for the mouse germline appears achievable.
Conclusions:
- Mini-chromosome vectors offer novel experimental approaches for genetic problems.
- This technology may significantly speed up gene identification in mice.
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01:51Lampbrush Chromosomes
In 1882, Flemming observed lampbrush chromosomes (LBC) in salamander eggs. Later in 1892, Rückert observed LBCs in shark egg cells and coined the term "lampbrush chromosomes" because they looked like brushes used to clean kerosene lamps.
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops resemble the...