Related Experiment Videos
Novel monoacetoneglucose derivatives with calcium antagonist activity
T Bécaert1, P Vanlemmens, P Villa
1Laboratoire de Neurobiologie Cellulaire, Faculté des Sciences-Université de Picardie Jules Verne, Amiens, France.
Bollettino Chimico Farmaceutico
|March 1, 1996
Abstract:
Ethers and thioethers of monosaccharides have been synthesised which show potent toxicity to mouse (LD50 > or = 4 g.kg-1 O.W. and 0.2 to 1.5 g.kg-1 I.P.W.). A study of calcium antagonist activity for the full series of compounds indicated that the activity was similar for both O- and S- ethers and maximum activities were observed for monoacetoneglucose ethers possessing carbon chain close to 8 carbons.