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Short-bowel syndrome

N H Stollman1, B R Neustater, A I Rogers

  • 1Division of Gastroenterology, University of Miami School of Medicine, FL, USA.

The Gastroenterologist
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

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Short-bowel syndrome (SBS) occurs after significant small intestine resection, causing malabsorption and malnutrition. Intestinal adaptation and advanced nutrition therapies improve patient outcomes.

Area of Science:

  • Gastroenterology
  • Surgical Science
  • Nutritional Science

Background:

  • Short-bowel syndrome (SBS) results from extensive small intestine resection.
  • Clinical features include diarrhea, dehydration, malabsorption, and malnutrition.
  • While bowel length is key, other factors influence outcomes.

Purpose of the Study:

  • To review the anatomical and pathophysiological basis of SBS.
  • To discuss clinical manifestations and intestinal adaptation.
  • To cover current therapeutic and nutritional management strategies.

Main Methods:

  • Literature review of anatomical and pathophysiological data.
  • Synthesis of clinical manifestations and adaptation knowledge.
  • Overview of medical, surgical, and nutritional interventions.

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Main Results:

  • Resection >75% of small intestine often leads to SBS symptoms.
  • Intestinal adaptation occurs over months to years but underlying agents are unclear.
  • Total parenteral nutrition has significantly improved SBS prognosis.

Conclusions:

  • Understanding SBS pathophysiology is crucial for management.
  • Intestinal adaptation mechanisms require further elucidation.
  • Comprehensive care involving nutrition and therapeutics optimizes outcomes.