Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Focal segmental glomerulosclerosis

I Ichikawa1, A Fogo

  • 1Division of Pediatric Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Pediatric Nephrology (Berlin, Germany)
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two-staged, adaptive placebo-controlled trial (APRICOT).

The British journal of dermatology·2021
Same author

Mr. Fogo's Remarks on a Case of Phthisis.

The Medical and physical journal·2018
Same author

Mr. Fogo, in Answer to Dr. Trotter.

The Medical and physical journal·2018
Same author

Dr. Fogo, on Certain Theories of Hydrocephalus.

The Medical and physical journal·2018
Same author

Mr. Fogo on Chronic Hepatitis.

The Medical and physical journal·2018
Same author

Mr. Fogo on Twin Cases.

The Medical and physical journal·2018
Same journal

Real-world experience of using vitamin E for symptomatic management of muscle cramps in children living with chronic kidney disease.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Feasibility and comparability in pediatric donation after circulatory death kidney transplantation.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

APOM-S1P axis as a therapeutic target in steroid sensitive nephrotic syndrome.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Atypical renal phenotype with tubular proteinuria and hypercalciuria in siblings with nail-patella syndrome: evidence for a dual genetic diagnosis.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Blood pressure control in pediatric hemodialysis: data from the SCOPE collaborative.

Pediatric nephrology (Berlin, Germany)·2026
Same journal

Correlation between urinary soluble CD163 and endocapillary proliferation and fibrinoid necrosis in IgA vasculitis with nephritis.

Pediatric nephrology (Berlin, Germany)·2026
See all related articles

Focal segmental glomerulosclerosis (FSGS) is a common cause of kidney disease progression in adults and children. While treatments like steroids and ACE inhibitors show promise, FSGS is complex, and transplantation remains vital for end-stage renal disease.

Area of Science:

  • Nephrology
  • Pathology
  • Immunology

Background:

  • Focal segmental glomerulosclerosis (FSGS) is a significant cause of progressive kidney disease in both pediatric and adult populations.
  • FSGS can manifest as a primary lesion or underlie various renal diseases, including HIV infection and glycogen storage disease.
  • The precise triggers for primary FSGS remain elusive, despite identified pathophysiological pathways leading to end-stage renal disease.

Purpose of the Study:

  • To review the current understanding of FSGS as a common pathway in renal disease.
  • To discuss the known pathophysiological events and emerging therapeutic strategies for FSGS.
  • To evaluate the role of interventions like steroid pulse therapy and ACE inhibitors in primary FSGS.

Main Methods:

  • Literature review of laboratory and clinical studies on FSGS.

Related Experiment Videos

  • Analysis of therapeutic outcomes from uncontrolled studies and established treatment guidelines.
  • Examination of the role of angiotensin and its inhibitors in renal disease progression.

    • Main Results:

    • Intravenous steroid pulse therapy has shown potential for inducing remission in FSGS, though its long-term impact on chronic renal failure risk is unconfirmed.
    • Angiotensin converting enzyme inhibitors are effective in secondary glomerulosclerosis, but their efficacy in primary FSGS requires further verification.
    • Renal transplantation offers a vital therapy for FSGS patients with end-stage renal disease, with improved allograft survival rates outweighing recurrence risks.

    Conclusions:

    • FSGS represents a spectrum of lesions rather than a single disease entity.
    • Prognosis and optimal therapeutic strategies are influenced by lesion type and individual genetic factors.
    • Continued research is needed to elucidate primary FSGS mechanisms and refine treatment approaches.