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Rapid detection of chemical carcinogens by measuring RNA released from microsomes in post-mitochondrial supernatant
J S Dhanda1, H M Dani, R Sharma
1Department of Biochemistry, Panjab University, Chandigarh, India.
Indian Journal of Experimental Biology
|June 1, 1996
Abstract:
Incubation of carcinogens with post-mitochondrial supernatant (PMS) and NADPH releases ribosomes from microsomes resulting in increased RNA concentration in post-microsomal supernatant. However, non-carcinogens fail to do so. Enhanced concentration of RNA in test over control samples can provide a useful index for the carcinogenicity of environmental pollutants.