Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Irreversible sinus node dysfunction induced by resumption of lithium therapy

T Terao1, H Abe, K Abe

  • 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.

Acta Psychiatrica Scandinavica
|May 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stimulation of the hamster ventral lateral geniculate nucleus induces Fos-like immunoreactivity in suprachiasmatic nucleus cells.

Neuroscience letters·1992
Same author

Papillary craniopharyngioma of the third ventricle--case report.

Neurologia medico-chirurgica·1992
Same author

Sequential change of heterogeneous cerebral blood blow patterns after diffuse brain ischemia.

Resuscitation·1992
Same author

Cerebral infarction in a heterozygote with variant antithrombin III.

Stroke·1992
Same author

Ocular convergence-related neuronal responses in the lateral suprasylvian area of alert cats.

Neuroscience research·1992
Same author

[Evaluation of cerebral blood circulation using fast magnetic resonance imaging (turbo-FLASH)].

No shinkei geka. Neurological surgery·1992
Same journal

Reevaluating the Role of ADHD Perceptions in Medication Continuation: Methodological and Interpretative Considerations.

Acta psychiatrica Scandinavica·2026
Same journal

AI-Associated Psychotic Phenomena: Collect Before You Classify.

Acta psychiatrica Scandinavica·2026
Same journal

Developmental Trauma as a Prognostic Factor for Later Psychotic Disorder in an Adolescent Clinical Cohort: A 20-Year Follow Up Study.

Acta psychiatrica Scandinavica·2026
Same journal

The Prevalence of Obstructive Sleep Apnoea in Schizophrenia, Bipolar Disorder and Major Depressive Disorder: A Systematic Review With Meta-Analysis.

Acta psychiatrica Scandinavica·2026
Same journal

Use of Glucagon-Like Peptide 1 Receptor Agonists and the Associated Risk of Hospitalisation in Bipolar Disorder, From a Nationwide Cohort, 2009-2024.

Acta psychiatrica Scandinavica·2026
Same journal

Benzodiazepine Use and Mortality Risk: A Nationwide Cohort Study on New Benzodiazepine Users With a 5-Year Follow-Up.

Acta psychiatrica Scandinavica·2026
See all related articles

Long-term lithium therapy can cause severe sinus node dysfunction, leading to syncope. This risk may be irreversible, necessitating pacemaker implantation even after lithium discontinuation.

Area of Science:

  • Cardiology
  • Pharmacology
  • Electrophysiology

Background:

  • Lithium is a mood stabilizer used for bipolar disorder.
  • Sinus node dysfunction (SND) affects heart rhythm.
  • Long-term lithium use has potential cardiac side effects.

Observation:

  • A 56-year-old woman experienced syncope due to SND after prolonged lithium treatment.
  • Her sinus node function recovered upon lithium cessation.
  • SND recurred with low-dose lithium and became irreversible after subsequent discontinuation.

Findings:

  • Lithium therapy can induce severe and potentially irreversible sinus node dysfunction.
  • Prior recovery of sinus node function does not preclude irreversible damage upon lithium re-challenge.

Related Experiment Videos

  • This case highlights a rare but serious risk associated with lithium treatment.

    • Implications:

    • Clinicians should monitor for cardiac arrhythmias, particularly SND, in patients on long-term lithium.
    • Irreversible SND is a potentially fatal complication requiring permanent pacemaker implantation.
    • The risk of irreversible cardiac effects necessitates careful patient selection and monitoring during lithium therapy.