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Cardiomyopathy associated with clozapine

R J Leo¹, J L Kreeger, K Y Kim

¹Department of Psychiatry, School of Medicine and Biomedical Sciences, State University of New York (SUNY) at Buffalo 14215, USA.

The Annals of Pharmacotherapy

|June 1, 1996

Summary

Clozapine, an antipsychotic, can rarely cause symptomatic cardiomyopathy. This case highlights the importance of cardiac monitoring in patients receiving clozapine therapy, especially those with pre-existing heart conditions.

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Area of Science:

Pharmacology
Cardiology
Psychiatry

Background:

Clozapine is an atypical antipsychotic used for schizophrenia.
Cardiac complications are a known, though rare, side effect of clozapine.

Observation:

A patient with schizophrenia developed cardiomyopathy during clozapine treatment.
Symptoms included dyspnea, malaise, and edema with reduced ejection fraction.

Findings:

This case demonstrates clozapine-induced symptomatic cardiomyopathy.
Review of literature indicates cardiorespiratory complications are rare but possible.

Implications:

Caution is advised when using clozapine in patients with cardiac disease.
Concurrent use of benzodiazepines may increase risk.

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Regular cardiac monitoring is crucial for patients on clozapine.