Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synaptic dysfunction in Alzheimer's disease: clinical assessment using quantitative EEG

I A Cook1, A F Leuchter

  • 1UCLA Neuropsychiatric Institute, USA. cook@qeeg.npi.ucla.edu

Behavioural Brain Research
|June 1, 1996
PubMed
Summary

Quantitative EEG measures like cordance and coherence offer a non-invasive way to assess synaptic dysfunction. These methods help study brain disorders such as Alzheimer's disease and normal brain development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of psychotropic drugs on cortical excitability and plasticity measured with transcranial magnetic stimulation: Implications for psychiatric treatment.

Journal of affective disorders·2019
Same author

Cognitive rehabilitation group intervention for breast cancer survivors: results of a randomized clinical trial.

Psycho-oncology·2015
Same author

Evaluation of quantitative EEG by classification and regression trees to characterize responders to antidepressant and placebo treatment.

The open medical informatics journal·2011
Same author

Brain functional changes (QEEG cordance) and worsening suicidal ideation and mood symptoms during antidepressant treatment.

Acta psychiatrica Scandinavica·2010
Same author

Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D (Sequenced Treatment Alternatives to Relieve Depression) report.

Psychological medicine·2009
Same author

Brain functional changes during placebo lead-in and changes in specific symptoms during pharmacotherapy for major depression.

Acta psychiatrica Scandinavica·2008

Area of Science:

  • Neuroscience
  • Neurophysiology
  • Brain Imaging

Background:

  • Synaptic plasticity is crucial for central nervous system functions, including brain development, learning, and memory.
  • Disruptions in synaptic function are implicated in various neuropsychiatric disorders, such as epilepsy and Alzheimer's disease.

Purpose of the Study:

  • To investigate synaptic dysfunction in Alzheimer's disease and other dementias using quantitative EEG (QEEG) measures.
  • To explore the utility of QEEG cordance and coherence for assessing synaptic function in the human brain.

Main Methods:

  • Utilized quantitative EEG (QEEG) measures, specifically cordance and coherence.
  • Applied these non-invasive methods to study the intact, living human brain in elderly individuals with dementing illnesses.

Related Experiment Videos

Main Results:

  • Identified regional brain dysfunction associated with altered synaptic connectivity in patients with Alzheimer's disease and other dementias.
  • Demonstrated the feasibility of using QEEG cordance and coherence to assess synaptic function.

Conclusions:

  • QEEG cordance and coherence are valuable tools for non-invasively assessing synaptic dysfunction in the human brain.
  • These techniques can be applied to study neurophysiology in neurodegenerative diseases, normal brain development, and adaptive functioning.