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A decrease in antiphospholipid antibodies before a thrombotic event

S Praprotnik¹, B Bozic

¹University Medical Centre, Dept. of Rheumatology, Ljubljana, Slovenia.

Clinical Rheumatology

|May 1, 1996

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In patients with antiphospholipid syndrome, antiphospholipid antibodies (aPL) may trigger thrombosis, even as levels decrease during the acute phase. These antibody levels remained low post-thrombosis, suggesting a role in provocation rather than consumption.

Area of Science:

Rheumatology
Hematology
Immunology

Background:

Systemic lupus erythematosus (SLE) is an autoimmune disease.
Antiphospholipid syndrome (APS) is a condition associated with an increased risk of blood clots.
Thrombosis, or blood clot formation, can occur in various parts of the body.