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Disease mechanism: unravelling Wiskott-Aldrich syndrome
1Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Current Biology : CB
|June 1, 1996
Abstract:
The gene responsible for Wiskott-Aldrich syndrome, a disease affecting platelets and lymphocytes, has been cloned and its protein product (WASp) found to interact with the GTPase Cdc42. WASp seems to provide a link between Cdc42 and the actin cytoskeleton, perhaps explaining the cellular defects underlying the disease.