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Mammalian artificial chromosomes
W Brown1, R Heller, M L Loupart
1CRC Chromosome Molecular Biology Group, Biochemistry Department, Oxford University, UK. wrab@bioch.ox.sc.uk
Current Opinion in Genetics & Development
|June 1, 1996
Abstract:
The development of candidate vectors and of techniques for their manipulation by sequence targeting suggest that a mini-chromosome vector system for the mouse germline may be at hand. Mini-chromosome vectors should allow new sorts of genetic problems to be addressed experimentally and may accelerate the process of gene identification.