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Tissue polypeptide antigen during parturition and puerperium
A Bergant1, H Kirchler, H Schröcksnadel
1Department of Obstetrics and Gynecology, University of Innsbruck, Austria.
Gynecologic and Obstetric Investigation
|January 1, 1996
Summary
Maternal serum levels of tissue polypeptide antigen (TPA) are elevated during labor, correlating with labor duration and inversely with placental weight. TPA levels decrease rapidly postpartum.
Area of Science:
- Biochemistry
- Obstetrics
- Oncology
Background:
- Tissue polypeptide antigen (TPA) is a tumor and cytoskeleton protein.
- Maternal serum TPA levels during pregnancy and postpartum are not well-characterized.
Purpose of the Study:
- To investigate maternal serum TPA levels during the second stage of labor and the 4th postpartum day.
- To explore correlations between TPA levels and labor duration, placental weight, and postpartum decline.
Main Methods:
- Maternal serum samples were collected during the second stage of labor, on the 4th postpartum day, and from a control group of pregnant women at term.
- Tissue polypeptide antigen (TPA) concentrations were determined using immunoassay.
- Statistical analysis included correlation and significance testing.
Main Results:
- TPA levels were significantly higher during parturition (median 169 U/l) compared to term controls (median 108.5 U/l) and the 4th postpartum day (median 66.5 U/l) (p < 0.0001).
- A positive correlation was observed between labor duration and TPA concentration (rs = 0.3; p = 0.03).
- A negative correlation was found between placental weight and maternal serum TPA levels during parturition (rs = -0.3; p = 0.03).
Conclusions:
- Maternal serum TPA levels increase during labor and decline rapidly postpartum, with a serum half-life of less than 4 days.
- TPA levels during parturition are influenced by labor duration and placental weight.